This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.
Katsumi Matsuzaki is a Professor at the Graduate School of Pharmaceutical Sciences, Kyoto University, where he also completed his PhD in Biophysical Chemistry. Dr. Matsuzaki has authored more than 100 publications, which have been cited more than 10000 times. In addition to serving as an editor for Biochimica et Biophysica Acta-Biomembranes, Journal of Peptide Science, and European Biophysics Journal, he is a member of the Biophysical Society (USA), The Pharmaceutical Society Japan, The Japanese Peptide Society, and The Biophysical Society of Japan. He was awarded The Japanese Peptide Society Award for Young Scientists, The Pharmaceutical Society Japan Award for Young Scientists, and the Erwin von Bälz Prize. His primary research interest is in membrane biophysics, including peptide-membrane interactions and in-cell biophysics.