Wearable Biosensing in Medicine and Healthcare

This book contains chapters on wearable biomedical sensors and their assistive technologies for promoting behavioral change in medical and health care. Part I reviews several wearable biomedical sensors based on biocompatible materials and nano and micro-electromechanical systems (MEMS) technologies in the medical and dental fields. Part II introduces the latest approaches to wearable biosensing using unique devices for various skin targets such as sweat, interstitial fluid, and transcutaneous gases. Part III presents technologies supporting wearable sensors, including soft and flexible materials, manufacturing methods, skin volatile-marker imaging, and energy harvesting devices.
This book is intended for graduate students, academic researchers, and professors that work in medical and healthcare research fields, as well as industry professionals involved in the development of wearable and flexible sensing devices and measurement systems for human bio/chemical sensing, medical monitoring, and healthcare services, and for medical professionals and government officials who are driving behavior change in health care.


Kohji Mitsubayashi received his Ph.D. from The University of Tokyo in 1994. Since 2003, he has been a professor at the Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University. His research interests include wearable biosensors, gas sensors for non-invasive bio-monitoring, and novel battery-free artificial organs (pancreas, muscles) with 'Organic Engine (chemo-mechanical energy converter with biosensing technology).'
He has proposed a new device category 'Cavitas sensors' in human body cavities for real-time bio-monitoring such as 'Soft contact lens glucose sensors' (1995, 2008, 2009, and 2011), 'Telemetric mouthguard sensors with a Bluetooth transmitter' (2016 and 2020), 'Optic pharyngeal manometric sensor for deglutition analysis' (2007), etc. In 1988, he also started to develop several types of gas-phase biosensors (bio-sniffer, sniff-cam). They allow for real-time sensing and imaging of target volatiles in exhaled air, and skin gas (food and drink) with good sensitivity, gas-selectivity, and insensitivity to humidity.